Marburg Fever — Worldwide/Unknown
Coffin KM, Liu J, Warren TK, et al. Persistent Marburg Virus Infection in the Testes of Nonhuman Primate Survivors. Cell Host & Microbe, In Press, Corrected Proof. Available online 30 Aug 2018.
Highlights
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– Marburg virus (MARV) persists in the testes of macaque survivors after treatment
– MARV infiltrates macaque testes late in infection
– MARV persists in testicular Sertoli cells, thereby disrupting tissue barrier integrity
– Local immunosuppressive T-reg cell infiltration
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