Tag Archive for PRO/EDR> HIV – USA: (AZ) CRISPR
PRO/EDR> HIV – USA: (AZ) CRISPR
HIV/AIDS -- United States"CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an obstacle to overcome. Here, we demonstrate the feasibility and efficiency of excising the HIV-1 provirus in 3 different animal models using an all-in-one adeno-associated virus (AAV) vector to deliver multiplex single-guide RNAs (sgRNAs) plus _Staphylococcus aureus_ Cas9 (saCas9). The quadruplex sgRNAs/saCas9 vector outperformed Read more [...]
