Chronic/Non-Infectious Disease — Worldwide/Unknown
Background
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The giant [free] DNA viruses, such as the _Acanthamoeba polyphaga mimivirus_, express collagen-like proteins that are similar to animal collagens. Although mimiviruses replicate in amoebae, the authors of this paper show that a 3rd of human beings display a serum IgG response against the main mimivirus capsid protein and that antibodies against a mimivirus collagen were frequent in persons with rheumatoid arthritis. The capacity of mimivirus to elicit antibody responses
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