PRO/AH/EDR> COVID-19 update (143): questions, VITT, ECMO, obesity, WHO, global

COVID-19 — Worldwide/Unknown
Background: SARS-CoV-2 vaccine ChAdOx1 nCov-19 rarely causes vaccine-induced immune thrombotic thrombocytopenia (VITT) that — like autoimmune heparin-induced thrombocytopenia — is mediated by platelet-activating anti-platelet factor 4 (PF4) antibodies.
Methods: We investigated vaccine, PF4, and VITT patient-derived anti-PF4 antibody interactions using dynamic light scattering, 3D-super-resolution microscopy, and electron microscopy. Mass spectrometry was used to analyze vaccine