PRO/AH/EDR> Hepatitis non-A/B/C/D/E: parvovirus-like hybrid

Hepatitis — Worldwide/Unknown
Abstract
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Seronegative hepatitis — non-A, non-B, non-C, non-D, non-E hepatitis — is poorly characterized but strongly associated with serious complications. We collected 92 sera specimens from patients with non-A-E hepatitis in Chongqing, China between 1999 and 2007. 10 sera pools were screened by Solexa deep sequencing. We discovered a 3780-bp contig present in all 10 pools that yielded BLASTx E [basic local alignment search tool] scores of 7e-05-0.008 against parvoviruses. The